Skunks are subject to the same parasites as dogs and cats – fleas, ticks, intestinal parasites such as worms, giardia, coccidia, all are on the the attack.
Common roundworms are easy to treat. Veterinarians recommend an over-the-counter medication called Pyrantel Pamoate which kills hookworms, roundworms and pinworms. A fecal check at the vet will tell exactly which internal parasite your skunk may have. Other internal parasites have to be treated with veterinary prescribed medications.
To rid your pet skunk of fleas, give him/her a bath using dish soap. This will drown the fleas. DON’T use flea shampoo. Vacuum the entire house and do so often to keep fleas away. Bedding, toys and anything else washable can go into the washing machine. Sprinkle food grade diatomaceous earth throughout the garden/backyard. Make sure it is food grade. You can even mix some, about 1/4 to 1/2 teaspoon daily in your skunk’s food. DON’T use over-the-counter flea preventatives as they can be toxic to your skunk. Check with your exotic pet vet for a safe product for a flea infestation.
Yearly deworming and treating your skunk, the house and the garden before the fleas appear help to keep those critters away.
Note: There is a product called Mycodex Plus Environmental Aerosol Household Spray, but I cannot recommend it although others have. You and your pets have to leave the house to use the spray and wait until it dries. But pets don’t wear shoes and the residue can be picked up on their fur or skin where they will lick it off. Not a tasty treat you want for your pet.